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This Week in Infectious Disease
Infectious Disease · Week of Apr 7, 2026
Paper 1 of 5
NEJM Randomized Controlled Trial · 4,847 patients
Ceftazidime-avibactam versus meropenem for carbapenem-resistant Enterobacterales bloodstream infections: a multicenter RCT
Why it matters
CRE bloodstream infections carry 40–70% mortality. First large RCT to compare new beta-lactam/beta-lactamase inhibitor combinations head-to-head.
Key finding
Ceftazidime-avibactam achieved 28-day all-cause mortality of 24% vs. 34% for meropenem (OR 0.61, 95% CI 0.48–0.78). NNT of 10.
Limitation
Open-label design; 78% of patients had KPC-producing isolates, limiting generalizability to other resistance mechanisms (OXA, NDM).
For your practice
Positions ceftazidime-avibactam as first-line for KPC-CRE bacteremia when susceptibility is confirmed — if it's available at your institution.
Abstract (NEJM) Full text — open access Save for later
5 papers this week · 3 min read each
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